Dr Jane Ellen Simmons is Chief of the Pharmacokinetics Branch, National Health and Environmental Effects Research Laboratory, U.S. EPA. She has an M.S.P.H. in Environmental Management and Protection and a Ph.D. in Toxicology from the Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill. She has authored more than 90 peer-reviewed journal articles and 15 book chapters and reports. Her research focus areas include: models, methods and approaches for both defined mixtures and environmentally realistic complex mixtures; integrating chemical and toxicological evaluations of chemical mixtures; combined chemical and nonchemical stressors; factors that influence toxicity; and, pharmacokinetics, including physiologically-based pharmacokinetic modeling. She is a Diplomate of the American Board of Toxicology. For the Society of Toxicology, Dr. Simmons has served as President of the Mixtures Specialty Section, on the Nominating Committee, the Mixtures Task Force, and the Organizing Committee of a Contemporary Topics in Toxicology meeting; she has chaired multiple continuing education courses. She co-chaired the International Toxicology of Mixtures Conference and has served on the HiWate Science Advisory Board, on review panels for the Food and Drug Administration and North Carolina State University and Advisor to the EPA RTP Chapter of the National Training Leadership Organization.